Friday, 9 June 2017

Diminished ROS Production in Neonatal Polymorphonuclear Leukocytes Stimulated with Escherichia coli


Bacterial infection in neonates, especially in immature preterm neonates, causes death and has a key role for long-term morbidity of those infants. The reason of this phenomenon is mainly due to the immaturity of bactericidal mechanisms in innate immunity. Neutrophils (PMNs: Polymorphonuclear leukocytes) are primaryresponders maintaining nonspecific innate immunity against bacterial invasion. 
 
Neonatal Polymorphonuclear Leukocytes
 The principal functions exhibited by circulating PMNs in response to bacterial invasion and inflammation include adherence to the vascular endothelium, deformability, chemotaxis, phagocytosis and intracellular microbial killing. In neonates, the ability of PMNs adherence, deformability and chemotaxis are known to be low because of the immaturity of neutrophil structure.Read more>>>

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